Relative Bioavailability of Carvedilol after Oral, Rectal and Intravenous Administration in Rats.
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چکیده
منابع مشابه
Effects of cilostazol on the pharmacokinetics of carvedilol after oral and intravenous administration in rats.
This study was designed to investigate the effects of cilostazol on the pharmacokinetics of carvedilol following oral or intravenous administration of carvedilol in rats. Clinically carvedilol and cilostazol can be prescribed for treatment of cardiovascular diseases. Carvedilol and cilostazol are all substrates of CYP2C9 enzymes. Carvedilol was administered orally or intravenously without or wi...
متن کاملEffects of Glipizide on the Pharmacokinetics of Carvedilol after Oral and Intravenous Administration in Rats
scavenges free radicals of oxygen (Feuerstein et al., 1997). It is used to treat systemic arterial hypertension (Cournot et al., 1992; Lund-Johansen et al., 1992) and congestive heart failure (DasGupta et al., 1991) and is purported to improve exercise capacity (Cleland et al., 1996; Hampton, 1996) and longevity in humans (Bristow et al., 1996). Carvedilol is well absorbed from the gastrointest...
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BACKGROUND 6-Mercaptopurine and its prodrug azathioprine are effective medications for refractory inflammatory bowel disease. However, use of these drugs has been limited by concerns about their toxicity. Colonic delivery of azathioprine may reduce its systemic bioavailability and limit toxicity. AIM To determine the bioavailability of 6-mercaptopurine after administration of azathioprine via...
متن کاملOral bioavailability of ATP after prolonged administration.
Purinergic receptors are important for the regulation of inflammation, muscle contraction, neurotransmission and nociception. Extracellular ATP and its metabolites are the main ligands for these receptors. Occasional reports on beneficial results of ATP administration in human and animal studies have suggested the bioavailability of oral ATP supplements. We investigated whether prolonged daily ...
متن کاملEffects of Silibinin on the Pharmacokinetics of Carvedilol after Oral Administration in Rats
− This study was designed to investigate the effects of silibinin on the pharmacokinetics of carvedilol after oral administration of carvedilol in rats. Carvedilol was administered orally (3 mg/kg) with oral silibinin (0.3, 1.5 or 6 mg/ kg) and intravenously (1 mg/kg) to rats. The effects of silibinin on P-glycoprotein (P-gp) and cytochrome P450 (CYP) 2C9 and CYP2D6 activity were also evaluated...
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ژورنال
عنوان ژورنال: Japanese Journal of Hospital Pharmacy
سال: 1999
ISSN: 2185-9477,0389-9098
DOI: 10.5649/jjphcs1975.25.567